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Complication of Minimal Change Nephrosis

  Complication of Minimal Change Nephrosis

  Patients with hypoalbuminemia for long-term can cause malnutrition or infection. High coagulation state can lead to thrombosis, Inappropriate diuresis and ban salt can appear low sodium or hypokalemia.

  1. Infection.

  Before the advent of antibiotics, infection is a common cause of death, disease, especially in pediatric patients with pathogenic bacteria mainly for pneumonic diplococcus, hemolytic streptococcus. It can cause peritonitis, pleurisy, subcutaneous infections and respiratory infections even cause urinary tract infections. Especially in adrenal cortical hormone and immunosuppressive drug treatment, often aggravate bacterial infections, also increased susceptibility to infection, such as the herpes virus, susceptibility to measles virus.

  2. Thrombosis, embolism complications.

  Arterial and venous thrombosis in patients with nephrotic syndrome, such as pulmonary embolism and thrombosis, peripheral arterial and venous thrombosis. Most of renal vein thrombosis for subclinical type, but can also occur severe proteinuria, hematuria, and even kidney failure. Femoral artery embolism is one of the emergency state of this disease, such as not timely thrombolysis treatment, which can lead to limb amputation. Inprovement and low capacity of blood concentration, increased blood viscosity, strong diuretic and long-term use of glucocorticoid and increased high coagulation state.

  3. Hyperlipidemia.

  Long-term hyperlipidemia, especially LDH increase HDL decreased. May cause coronary heart disease and atherosclerosis. As a result, it can cause mesangial cell proliferation and mesangial matrix increased, thereby aggravating glomerular sclerosis of progressive.

  4. Renal injury.

  (1)Acute renal injury in patients with this disease clinical showed severe blood volume decline in oliguria, no urine, urinary sodium, limb small appetite, blood pressure drops, pressing of arteries and veins, hematocrit increased and the characteristics of acute renal failure, this belongs to the renal oliguria, It is easy to use the plasma or the plasma protein to correct. Sometimes in a large number of patients with proteinuria without blood volume to reduce, it also be acute renal failure, and glomerular filtration rate dropped significantly, interstitial edema oppression renal tubules, proteinuria type tube obstruction and other factors.

  (2)The renal tubular function damage: nephrotic syndrome caused by diseases are the basis of renal tubular damage, a large amount of urinary protein, renal tubular atrophy and interstitial fibrosis, especially near the convoluted tubules dysfunction that characterized by hypokalemia, renal glycosuria, aminoaciduria, acidosis and so on.

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