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Reduced uric acid protects kidney function

  2016 American Association of Rheumatology (ACR / ARHP) released the latest research results show that lowering uric acid levels can improve renal function in patients with chronic kidney disease.

  At present, the first-line drugs to reduce uric acid with allopurinol and fosobutan, to determine whether patients with chronic kidney disease can benefit from uric acid (uric acid control target <6mg / dl) treatment, and CKD staging will affect patients The benefits of lowering uric acid therapy (ULT) have been studied by Gerald Levy's team.

  Gerald Levy said, "Progress in chronic kidney disease to end-stage renal disease, the need for dialysis or renal transplantation, seriously affecting the quality of life of patients, increasing the burden of medical treatment.Ethronephritis prevention of the main method is to control diabetes and high blood pressure; maintain normal uric acid levels May be another effective way to prevent the progression of kidney disease.

  The retrospective cohort study (2008-2014) included 12,751 patients with a serum uric acid level of> 7 mg / dl, 2,690 patients receiving uric acid lowering, and 10,061 patients not receiving uric acid therapy. At the end of the study, eGFR was 30% lower or 30% higher than baseline.

  The results showed that serum uric acid levels in control group were 42% in patients with uric acid lowering, 17.1% in those with 30% increase in eGFR and 30% in those who did not achieve the target level 10.4%.

  Patients with CKD stage 2, 3, and 4 had a 30% increase in eGFR: 7.1%, 19.9%, and 30%, respectively. The effect of CKD 3 treatment on improving renal function is the most obvious.

  The results showed that control of serum uric acid levels in patients with chronic kidney disease <6 mg / dl can significantly improve eGFR, and then improve renal function, prevent renal failure, reduce mortality.

  "The results suggest that patients with CKD should be monitored for uric acid levels with or without gout," he said. "Significant increases in serum uric acid levels and moderate renal failure, combined with uric acid therapy, help stabilize or improve renal function," the researchers conclude. . "

  Source: Urate-lowering therapy helps chronic kidney disease patients improve organ function. Medicalxpress.November 13, 2016


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